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Home > Products >  ICG-001

ICG-001 CAS NO.847591-62-2

  • Min.Order: 100 Milligram
  • Payment Terms: L/C,T/T,Western Union
  • Product Details

Keywords

  • (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
  • 780757-88-2
  • 847591-62-2

Quick Details

  • ProName: ICG-001
  • CasNo: 847591-62-2
  • Molecular Formula: C33H32N4O4
  • Appearance: white powder
  • Application: Colorectal cancer cell inhibitors
  • DeliveryTime: with stock
  • PackAge: foil bags
  • Port: Shanghai
  • ProductionCapacity: 1000 Gram/Year
  • Purity: 98%
  • Storage: Refrigerator
  • Transportation: By courier
  • LimitNum: 100 Milligram

Superiority

icg-001  is in stock. bulk available at low price, welcom to inquire the quoation through sales@xuntengchem.com.
 
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Details

 
Chemical structure
Code NO.
MT0554
ICG-001
Name
ICG-001
Synonym
ICG 001; ICG001
CAS NO.
847591-62-2 / 780757-88-2
Chemical Formula
C33H32N4O4
MW
548.63
Purity
>98%
Solubility(R.T.: 25℃)
DMSO ≥106mg/mL Water <1.2mg/mL Ethanol ≥42mg/mL
Stability
- 20, 2 years
 
Description
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
IC50 value: 3 uM
Target: Wnt
in vitro: ICG-001 has no effect on the related reporter construct, FOPFLASH, which contains mutated TCF sites. After treatment with 25μM of ICG-001 for 8 hours, SW480 cell reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein, both of which can be up-regulated by β-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells [1].  ICG-001, can phenotypically rescue normal nerve growth factor (NGF) -induced neuronal differentiation and neurite outgrowth in the presenilin-1 mutant cells, emphasizing the importance of the TCF/β-catenin signaling pathway on neurite outgrowth and neuronal differentiation [2]. A recent study demonstrates that 5μM ICG-001 inhibits leptin-induced EMT, invasion and tumorsphere formation in MCF7 cells [3].
in vivo: Administration of a water-soluble analog of ICG-001 for 9 weeks reduces the formation of colon and small intestinal polyps by 42% as effectively as the nonsteroidal antiinflammatory agent Sulindac, which has consistently demonstrated efficacy in this model. No overt toxicity is detected throughout the course of treatment. In the SW620 nude mouse xenograft model of tumor regression, 150 mg/kg, i.v. of analog demonstrates a dramatic reduction in tumor volume over the 19-day course of treatment, with no mortality or weight loss [1]. ICG-001 (5 mg/kg per day) significantly inhibits beta-catenin signaling and attenuates bleomycin-induced lung fibrosis in mice, while concurrently preserving the epithelium [4].

 

References

 

Attention
Sold for research purposes only; not for human, medical, veterinary, food or household use.

 

 

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